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Research and Development

Technology Background

Fast, simple and low-cost infection diagnostics directly at the patient bedside remains an unmet need in the health-care diagnostics market. Currently, rapid tests are available only for the simplest biological parameters (e.g. C-reactive protein, procalcitonin). For complex and life-threatening infectious illnesses however, reliable diagnostics can take place only through laborious and time-consuming procedures with the participation of a central laboratory employing qualified specialists. An example of such an illness is sepsis (“blood poisoning“). Of the approx. 240,000 Sepsis cases per year in Germany half must be treated in the intensive-care unit.

Treatment is complex, because most sepsis-cases are caused by more than 30 different pathogens that make up more than 90% of cases. Additionally some of these pathogens are already resistant against specific anti-fungals and antibiotics. To administer an effective a life-saving therapy, the physician must know which pathogen is present and which pharmaceutical is applicable for the treatment. With a mortality rate of 7% per hour following ICU admission it is critical that this information is conveyed to the physician as rapidly as possible.

Integration for a Functional Prototype

In this phase the individual steps of the laboratory model that are divided into separate modules are integrated to the MAZER functional prototype. Different model assays will be transferred to the MAZER system and adapted and optimized on the MinoCard.

In this way all process steps are integrated on a miniaturized compact diagnostics system. In addition a special sample preparation module, that can be connected to the universal MAZER card will be developed and tested.

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BMBF-Project MinoLab

Magna Diagnostics will provide a novel PoC magnetic-bead-based lab-on-a-chip diagnostic platform called "MAZER system" that is rapid, portable, easy to perform and reliable. The system will consist of a single-test “disposable” and an “analyser”. The analyser consists of the mechanic and electronic components that control the processes on the disposable, which is a microfluidic cartridge, acquires and manages the data, and displays the final results.

[more] MAZER system

EU-Project e-BRAINS: Best-Reliable Ambient Intelligent Nano Sensor Systems

Best-Reliable Ambient Intelligent Nano-sensor Systems e-BRAINS represent a giant leap for outstanding future applications in the area of ambient living with the ultimate need for integration of heterogeneous technologies, high-performance nano-sensor devices, miniaturization, smart wireless communication and best-reliability. e-BRAINS with minimum volume and weight as well as reduced power consumption can be utilized in ambient living systems. Successful market entry of such innovative ambient intelligence products will be determined by the performance improvement achieved and the cost advantage in relation to the total system cost. The basic requirement for robustness and reliability of the heterogeneous integration technologies and the nano-sensor layers is in the focus of all e-BRAINS developments.

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